Treatment for dysphagia by stimulation for TRV1 receptor and olfactory sense

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462607
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kochi University
• Principal Investigator: MATSUMOTO Shuichi 高知大学, 教育研究部医療学系臨床医学部門, 助教 (50633997)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: カプサイシン / 嚥下障害 / 嚥下内視鏡検査

Outline of Final Research Achievements

Swallowing videoendoscopy(VE) and swallowing videofluorography were performed on 14 patients with various swallowing disorders, and oral administration of capsaicin film was performed. After 4 weeks, VE was performed to evaluate the effect of swallowing improvement. Treatment was completed in 7 cases, and improvement of VE score was confirmed. In terms of items, swallowing reflex was evoked significantly improved. There were 7 cases of discontinuation of administration, 4 cases of dropout, discomfort, 2 cases of pause due to enhancement of cough reflex, 1 other case.
For healthy subjects, administration of capsaicin film for 4 weeks resulted in an increase in blood substance level P concentration.
TRV1 stimulation using capsaicin film is considered as a simple treatment method which can expect functional effect improvement effect on various dysphagia patients.

Free Research Field

医学、耳鼻咽喉科学、嚥下障害