Prediction of primary treatment outcome and prognosis by viral infection and tumor activity in head and neck cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462610
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of the Ryukyus
• Principal Investigator: Suzuki Mikio 琉球大学, 医学(系)研究科(研究院), 教授 (00226557)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 頭頸部癌 / ウイルス感染 / 生物学的活性 / 生活習慣 / 予後 / ヒト乳頭腫ウイルス / Epstein-Bar ウイルス

Outline of Final Research Achievements

Both of p16 immunohistochemistry and PCR for detecton of HPV-DNA/HPV insitu hybridization are needed to determine human papillomavirus (HPV)-related cancer. EB virus infection was only noted in nasopharyngeal cancer of various head and neck cancers. Metabolic tumor volume in PET study was related to prognosis of oropharyngeal cancer in treatment of concurrent chemoradiotherapy. Of various causes, laryngeal cancer was affected by smoking habit, and hypopharyngeal cancer by alcohol intake. De-escalation study about HPV-related cancer is now underway for patients with oropharyngeal cancer.

Free Research Field

頭頸部癌