Analysis of carcinogenesis mechanism induced by human papillomavirus using DNA methylation as an indicator

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of the Ryukyus
• Principal Investigator: Deng Zeyi 琉球大学, 医学(系)研究科(研究院), 外国人客員研究員 (50723863)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 頭頸部癌 / human papillomavirus / 喉頭乳頭腫 / Long control region / DNAメチル化 / SMG-1

Outline of Final Research Achievements

In this project, it was demonstrated that long control region (LCR) of HPV-16 in HPV-16 positive head and neck cancer (HNC) is often hypomethylated, and hypermethylation status of E2-binding Sites of HPV-16 frequently contributes to carcinogenesis in HNC. The extent of HPV-DNA methylation is not associated to the prognosis of HNC. Compared to HPV-DNA positive HNC, the higher level of SMG-1 mRNA expression in HPV-DNA negative HNC was observed. Lower SMG-1 mRNA expression may be associated with radiotherapy sensitivity in HNC. In addition, our findings revealed that the LCR of HPV-6 is frequently hypomethylated in laryngeal papilloma. Seven papers in English have published during 3 years of the research period.

Free Research Field

耳鼻咽喉頭頸部外科学分野