Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nara Medical University
• Principal Investigator: Ichiro Ota 奈良県立医科大学, 医学部, 講師 (00326323)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 癌幹細胞 / 浸潤・転移 / EMT / 糖尿病

Outline of Final Research Achievements

Abnormal glucose metabolism in cancer cells is known to be a major factor in cancer development. As a condition of diabetes, we investigated whether carbohydrate-specific carbohydrate metabolism abnormality induced EMT (Epithelial-Mesenchymal Transition) in hyperglycemic state promotes activation of cancer stem cells and enhances cancer invasion and metastasis. In addition, it also suggested that hyperglycemic state could affect the activation of cancer stem cells. Moreover, It was suggested that hyperglycaemic cancer cells have increased invasion and metastasis in vivo.

Free Research Field

医歯薬学