Analysis of HIF1-alpa expression for head and neck cancer metastasis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: Ozawa Hiroyuki 慶應義塾大学, 医学部(信濃町), 講師 (30327621)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Yoshihiro 慶應義塾大学, 医学部, 助教 (30445374) ; SATO Yoichiro 慶應義塾大学, 医学部, 助教 (40624440)
• Research Collaborator: Chung Christine Johns Hopkins University, Dept of Oncology Head and Neck therapeutic program
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 低酸素誘導因子

Outline of Final Research Achievements

The aim of the present study was to investigate the molecular targets of HIF1-α relevant to metastasis, and to find out an impact of HIF1-α to HNSCC metastasis by clinicopathological assays. In immunohistochemical study, the HIF-1α expression was higher in cancer cells than in normal cells of the adjacent normal mucosa. Univariate analysis revealed that high expression of HIF-1α was significantly correlated with T-classification (P=0.012), lymph node metastasis (P=0.002) and lymphatic invasion (P=0.03). HIF-1 inhibitor downregulated the expression of HIF-1α, twist, Oct3/4 and Nanog of head and neck cancer cells.
These results suggest that HIF-1α plays a key role for the tumor progression of HNSCC through EMT and CSC property. From the present study, HIF-1α inhibition may have the possibility to suppress tumor metastasis, thus HIF-1α is attractive target for the treatment of HNSCC.

Free Research Field

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