2016 Fiscal Year Final Research Report
Experimental application of piezoelectric actuator-driven pulsed water jets in retinal vein occlusion surgery
| Project/Area Number |
26462629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 硝子体手術 / パルスジェット / 網膜静脈閉塞 |
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| Outline of Final Research Achievements |
We found that at 0.025-ml/min, IOP stayed below 40 mmHg even after 3 min. Moreover, we found that a 0.025 ml/min ADPJ stream was stable at a pulse frequency of 10Hz, and that at this flow rate/frequency the ADPJ pressure was closely correlated with the applied voltage. The minimum voltage and distance to achieve intravenous displacement of the blood column (DBC) without causing retinal tearing or hemorrhage were 40 V and 0.5 mm, respectively. Furthermore, at this voltage (40V), consecutive OCT measurements revealed that this inner retinal swelling resolved within 1 week. Histological examination of the enucleated eyes 7 days after ADPJ massage showed that retinal areas near the massaged vessels were similar to areas near untreated vessels. With an appropriate flow rate and surgical time, ADPJ successfully induced massage of the retinal vessels and intravenous DBC while maintaining safe IOP and not causing retinal complications.
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| Free Research Field |
眼科学
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