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2016 Fiscal Year Annual Research Report

A comprehensive study on prevention of blindness from glaucoma

Research Project

Project/Area Number 26462633
Research InstitutionGifu University

Principal Investigator

山本 哲也  岐阜大学, 大学院医学系研究科, 教授 (50134581)

Co-Investigator(Kenkyū-buntansha) 川瀬 和秀  岐阜大学, 大学院医学系研究科, 准教授 (40234067)
望月 清文  岐阜大学, 医学部附属病院, 准教授 (90182162)
澤田 明  岐阜大学, 医学部附属病院, 講師 (80293570)
石田 恭子  東邦大学, 医学部, 准教授 (80334936)
石澤 聡子  岐阜大学, 医学部附属病院, 助教 (00362145)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords緑内障 / 失明予防 / 臨床研究 / 眼圧 / 視野
Outline of Annual Research Achievements

1. 緑内障治療改善プロジェクト ①緑内障手術用ミニシャントの有用性の検討: EX-PRESSミニシャントの臨床試験を継続実施し、眼圧並びに早期合併症の観点から検討した。眼圧は平均で12.4mmHgに下降した。角膜内皮細胞の有意の減少を認めた。前房フレア値は一過性に上昇した。②手術と薬物治療の眼圧体位変動に及ぼす影響の相違: Icare home眼圧計を用いた眼圧測定値の信頼性をGoldmann圧平眼圧計との比較、医師測定眼圧と患者測定眼圧との比較等により検討した。同眼圧計が自己測定可能な眼圧計として適していることを見出し、論文化した。③長期管理例の成績と予後因子解析:視野測定期間として15年以上の長期間管理した正常眼圧緑内障のデータを、線維柱帯切除術施行例、プロスタグランジン製剤投与例(眼圧下降率で2群に細分類)の3群に分けて解析した。その結果、手術による眼圧下降が視野の進行阻止に有効であること、また、薬物による眼圧下降が視野進行抑制に有効であることを見出し、論文化した。④濾過胞感染の予防及び予後改善:濾過胞感染を起こしていない緑内障術後眼の結膜から1年間に4回に渡り細菌培養を行った。うち、27%で細菌が検出された。Staphylococcus, P acnesが多く検出された。季節では秋と冬に多かった。
2. 緑内障早期発見プロジェクト ⑤眼底写真画像処理による自動早期診断:岐阜大学知能イメージ分野と共同研究を行い、緑内障眼の網膜神経線維層欠損の自動検出プログラムを改良し、論文化した。

  • Research Products

    (32 results)

All 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (24 results) (of which Int'l Joint Research: 14 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] Automated detection of nerve fiber layer defects on retinal fundus images using fully convolutional network for early diagnosis of glaucoma.2017

    • Author(s)
      Watanabe R, Muramatsu C, Ishida K, Sawada A, Hatanaka Y, Yamamoto T, Fujita H
    • Journal Title

      Proc SPIE Medical Imaging

      Volume: 印刷中 Pages: 印刷中

    • DOI

      1013438-1-1013438-7

    • Peer Reviewed
  • [Journal Article] Evaluation of a new rebound self-tonometer Icare HOME: comparison with Goldmann applanation tonometer.2017

    • Author(s)
      Takagi D, Sawada A, Yamamoto T
    • Journal Title

      J Glaucoma

      Volume: 印刷中 Pages: 印刷中

    • DOI

      10.1097/IJG.0000000000000674.

    • Peer Reviewed
  • [Journal Article] Effect of glaucoma implant surgery on intraocular pressure reduction, flare count, anterior chamber depth, and corneal endothelium in primary open-angle glaucoma.2017

    • Author(s)
      Ishida K, Moroto N, Murata K, Yamamoto T
    • Journal Title

      Jpn J Ophthalmol

      Volume: 印刷中 Pages: 印刷中

    • DOI

      10.1007/s10384-017-0512-2.

    • Peer Reviewed
  • [Journal Article] Protective effects of fluoroquinolones on UV-induced damage of cultured ocular cell lines.2017

    • Author(s)
      Nishida T, Kuse Y, Mochizuki K, Shimazawa M, Yamamoto T, Hara H
    • Journal Title

      Euro J Phrarmacol

      Volume: 印刷中 Pages: 印刷中

    • DOI

      10.1016/j.ejphar.2017.04.004

    • Peer Reviewed
  • [Journal Article] The impact of intraocular pressure reduction on progressive visual field in normal tension glaucoma followed over 15 years.2017

    • Author(s)
      Oie S, Ishida K, Yamamoto T:
    • Journal Title

      Jpn J Ophthalmol

      Volume: 印刷中 Pages: 印刷中

    • Peer Reviewed
  • [Journal Article] Development of glaucomatous visual field defects in preperimetric glaucoma patients within 3 years of diagnosis.2016

    • Author(s)
      Inuzuka H, Kawase K, Sawada A, Kokuzawa S, Ishida K, Yamamoto T
    • Journal Title

      J Glaucoma

      Volume: 25(6) Pages: 591-595

    • DOI

      10.1097/IJG.0000000000000260

    • Peer Reviewed
  • [Journal Article] Fluctuations of bacteria on bleb surface after trabeculectomy with adjunctive mitomycin C.2016

    • Author(s)
      Takahashi N, Sawada A, Mochizuki K, Katada T, Yamamoto T
    • Journal Title

      J Glaucoma

      Volume: 25(5) Pages: 433-439

    • DOI

      10.1097/IJG.0000000000000305

    • Peer Reviewed
  • [Presentation] What we have learned from mitomycin C trabeculectomy.2017

    • Author(s)
      Yamamoto T
    • Organizer
      2017 Spring Meeting of Taiwan Academy of Ophthalmology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2017-03-26
    • Int'l Joint Research / Invited
  • [Presentation] 家族性緑内障患者iPS細胞由来網膜神経節細胞の病態モデルの確立.2017

    • Author(s)
      稲垣賢、川瀬和秀、舩戸道徳、川瀬千鶴、関順子、大内一輝、嶋澤雅光、家島大輔、岩田岳、山本哲也、金子英雄、原英彰
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2017-03-17
  • [Presentation] Can trabeculectomy keep the visual field for life?2017

    • Author(s)
      Yamamoto T
    • Organizer
      The 32nd APAO Congress
    • Place of Presentation
      Singapore
    • Year and Date
      2017-03-04
    • Int'l Joint Research / Invited
  • [Presentation] Appositional and synechial closures in PAC.2017

    • Author(s)
      Yamamoto T
    • Organizer
      The 32nd APAO Congress
    • Place of Presentation
      Singapore
    • Year and Date
      2017-03-03
    • Int'l Joint Research / Invited
  • [Presentation] Automated detection of nerve fiber layer defects on retinal fundus images using fully convolutional network for early diagnosis of glaucoma.2017

    • Author(s)
      Watanabe R, Muramatsu C, Ishida K, Sawada A, Yamamoto T, Fujita H
    • Organizer
      SPIE Medical Imaging 2017
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2017-02-15
    • Int'l Joint Research
  • [Presentation] 正常眼圧緑内障における失明率:サブグループ解析.2016

    • Author(s)
      澤田明、小澤憲司、山本哲也
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都市
    • Year and Date
      2016-11-04
  • [Presentation] 手持ち自己眼圧測定計IcareHOMEの眼圧精度と有用性.2016

    • Author(s)
      高木大介、澤田明、山本哲也
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都市
    • Year and Date
      2016-11-03
  • [Presentation] Synechial and appositional closures in primary angle closure.2016

    • Author(s)
      Yamamoto T
    • Organizer
      The 12th Asia Angle Closure Glaucoma Club Meeting
    • Place of Presentation
      Yangon, Myanmar
    • Year and Date
      2016-10-24
    • Int'l Joint Research / Invited
  • [Presentation] 緑内障患者におけるSumi VDQスコアの解析.2016

    • Author(s)
      包文君、黄海龍、川瀬和秀、山本哲也、尾花明、岡部いづみ
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-09-17 – 2016-09-19
  • [Presentation] 後期緑内障における手術群と薬物群の5年間のmGCIPLの変化.2016

    • Author(s)
      犬塚裕子、澤田明、川瀬和秀、石澤聡子、山本哲也
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-09-17 – 2016-09-19
  • [Presentation] 濾過胞感染前に局所投与された治療薬の濾過胞感染への影響.2016

    • Author(s)
      佐柄英人、山本哲也、今泉公宏、石龍鉄樹
    • Organizer
      第27回日本緑内障学会会長賞口演
    • Place of Presentation
      横浜市
    • Year and Date
      2016-09-17
  • [Presentation] 家族性緑内障患者iPS細胞のオプチニューリン凝集に対するチモロールの作用.2016

    • Author(s)
      稲垣賢、川瀬和秀、舩戸道徳、大内一輝、嶋澤雅光、家島大輔、岩田岳、山本哲也、金子英雄、原英彰
    • Organizer
      第36回日本眼薬理学会
    • Place of Presentation
      東京都
    • Year and Date
      2016-09-11
  • [Presentation] Ageing and trabeculectomy.2016

    • Author(s)
      Yamamoto T
    • Organizer
      Glaucoma Research Society Meeting 2016 Seoul
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-01
    • Int'l Joint Research / Invited
  • [Presentation] Medical and surgical treatment of NTG.2016

    • Author(s)
      Yamamoto T
    • Organizer
      The 3rd APGC
    • Place of Presentation
      Chiang Mai, Thailand
    • Year and Date
      2016-07-15
    • Int'l Joint Research / Invited
  • [Presentation] The relationship between retinal layer thickness and visual function in different stages of primary open angle glaucoma.2016

    • Author(s)
      Tanaka H, Yamada W, Nishida T, Mochizuki K, Ishida K, Sawada A, Yamamoto T
    • Organizer
      12th EGS Congress
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2016-06-19 – 2016-06-22
    • Int'l Joint Research
  • [Presentation] Evaluation of the new rebound self-tonometer Icare HOME compared with Goldmann tonometer.2016

    • Author(s)
      Takagi D, Sawada A, Yamamoto T
    • Organizer
      12th EGS Congress
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2016-06-19 – 2016-06-22
    • Int'l Joint Research
  • [Presentation] Intermediate-term outcomes of Baerveldt glaucoma implant surgery in Japanese patients.2016

    • Author(s)
      Takahashi N, Yamada W, Tanaka H, Ishida K, Niimi Y, Mochizuki K, Yamamoto T
    • Organizer
      12th EGS Congress
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2016-06-19 – 2016-06-22
    • Int'l Joint Research
  • [Presentation] Evaluation of bleb characteristics after trabeculectomy, Ex-Press implantation, and tube shunt surgery.2016

    • Author(s)
      Ishida K, Nakano Y, Ojino K, Shimazawa M, Otsuka T, Kawase K, Hara H, Yamamoto T
    • Organizer
      12th EGS Congress
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2016-06-19 – 2016-06-22
    • Int'l Joint Research
  • [Presentation] Protective effect of fluoroquinolones of cultured ocular cell lines.2016

    • Author(s)
      Nishida T, Kuse Y, Mochizuki K, Yamamoto T , Shimazawa M, Hara H
    • Organizer
      12th EGS Congress
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2016-06-19 – 2016-06-22
    • Int'l Joint Research
  • [Presentation] The effect of the lateral decubitus position on intraocular pressure in normal volunteers.2016

    • Author(s)
      Kanno H, Sawada A, Yamamoto T
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-05
    • Int'l Joint Research
  • [Presentation] Legal blindness in normal tension glaucoma: a subgroup analysis.2016

    • Author(s)
      Ozawa K, Sawada A, Yamamoto T
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-02
    • Int'l Joint Research
  • [Presentation] トラボプロスト/チモロール配合薬とビマトプロストの眼圧下降効果の比較2016

    • Author(s)
      澤田明、山本哲也
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-04-08
  • [Presentation] 濾過胞感染発生率および治療に関する多施設共同研究における既定の治療戦略の有効性.2016

    • Author(s)
      庄司信行、新垣淑邦、中元兼二、山本哲也、桑山泰明、The CBIITS group
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-04-08
  • [Presentation] Epidemiology of Glaucoma in Japan2016

    • Author(s)
      山本哲也
    • Organizer
      第120回日本眼科学会総会 JOS-ARVO Joint Symposium
    • Place of Presentation
      仙台市
    • Year and Date
      2016-04-07
    • Invited
  • [Book] Bleb-related endophthalmitis. In: Durand ML, Miller JW, Young LH eds. Endophthalmitis.2016

    • Author(s)
      Yamamoto T, Mochizuki K, Sawada A
    • Total Pages
      139-150
    • Publisher
      Springer

URL: 

Published: 2018-01-16  

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