The immunological analysis for the development mechanism of the cytomegalovirus corneal endotheliitis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462639
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Yamaguchi University
• Principal Investigator: YAMADA Naoyuki 山口大学, 医学(系)研究科(研究院), 講師 (70437630)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: サイトメガロウイルス / 緑内障 / 水疱性角膜症 / マクロファージ / 移植免疫

Outline of Final Research Achievements

We analyzed chemokines in the aqueous humor from CMV corneal endotheliitis by Bio-Plex. The concentrations of IP-10 and MCP-1 which are monocyte chemoattractant were rising. These results showed the involvement of the macrophage for the development and recurrence of the CMV corneal endotheliitis. We also analyzed chemokines in the aqueous humor from HSV corneal endotheliitis, VZV corneal endotheliitis, and corneal graft rejection by Bio-Plex. In these diseases, the concentrations of IP-10 and MCP-1 were much higher than CMV. These results showed that the inflammation of CMV corneal endotheliitis is milder than other diseases.

Free Research Field

眼科学