Trial of treatment for the rodent model of nonarteritic ischemic optic neuropathy and investigation of vasodilating effect of steroid for the posterior ciliary artery.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462642
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Miyazaki
• Principal Investigator: CHUMAN HIDEKI 宮崎大学, 医学部, 准教授 (20244204)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 副腎皮質ステロイド / L-アルギニン / rNAION / 角膜電気刺激 / 単離短後毛様動脈 / 血管弛緩作用

Outline of Final Research Achievements

After induction of rodent model of nonarteritic ischemic optic neuropathy, we randomized three kinds of drugs which include saline, arginine, and steroid and injected each of them to the model. A steroid treatment group showed the most retinal ganglion cell (RGC) survival effect at the 56days after the treatment. A transcorneal electric stimulation (TES) did not show the significant RGC survival effect and TES plus arginine injection showed the significant RGC survival effect.
A methylprednisolone dilate the posterior ciliary artery in a dose dependent manner. In addition, they dilate these through nitric oxide independent mechanism.

Free Research Field

眼科学