2016 Fiscal Year Final Research Report
Role of aquaporin in retinal and optic nerve degenerative disorders
| Project/Area Number |
26462661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 視神経脊髄炎 / 緑内障 / 網膜神経節細胞 / アクアポリン / ヒト化免疫グロブリン / 光干渉断層計 |
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| Outline of Final Research Achievements |
An experimental neuromyelitis optica (NMO) model was established by exposing the rat optic nerve to sera from patients with anti-aquaporin 4 (AQP4) antibody-positive optic neuritis. Intravenous humanized immunogloblin G substantilly reduced the retinal ganglion cell (RGC) death. We demonstrated that the way how the AQP4 antibody positive optic neuritis damages the retinal tissue was different from the AQP4 antibody negative cases. We showed lacate transport through aquaporin 9 channel to be critical for the RGC survival.
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| Free Research Field |
眼科学
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