2016 Fiscal Year Final Research Report
Regulation of uveitis by inhibition of IkappaB kinase in mice
| Project/Area Number |
26462675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Ishijima Kan 北海道大学, 大学病院, 医員 (70634765)
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ぶどう膜炎 / 転写因子 / 新規薬剤 |
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| Outline of Final Research Achievements |
A new IkappaB kinase inhibitor, IMD-0354, was systemically injected into an animal model of human endogenous uveitis. Clinical severity of uveitis was significantly milder in treated mice than that of untreated control mice (p<0.05). It showed a dose-dependet effect. Pathological severity was also significantly milder in treated mice than controls (p<0.05). A new IkappaB inhibitor had a beneficial effect on regulating uveitis in mice.
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| Free Research Field |
眼科学
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