2016 Fiscal Year Final Research Report
Nucleic acid-based drug for corneal opacities
| Project/Area Number |
26462680
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
USUI TOMOHIKO 東京大学, 医学部附属病院, 准教授 (80282557)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 角膜 / 核酸医薬 / 血管新生 |
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| Outline of Final Research Achievements |
Nucleic acid drug is expected as new therapeutic tool for various diseases because of its high safety and economical aspects. Recently, we generate a single-stranded proline-modified short hairpin ribonucleric acid interference (RNAi) and micro-RNA (mi-RNA) molecule that is carried in a lipid nano-particle for topical application. This agent can penetrate all layers of the cornea and successfully inhibit the expressions of target molecules. This modified nucleic acid agent will be a new topical formulation for use against corneal diseases.
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| Free Research Field |
眼科
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