2016 Fiscal Year Final Research Report
A study for protective mechanisms of VGF, a neurosecretory peptide, in glaucomatous optic nerve degeneration
| Project/Area Number |
26462694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 網膜神経節細胞 |
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| Outline of Final Research Achievements |
In this study, we investigated the involvements of VGF in a mouse experimental glaucoma (optic nerve crush) model. Vgf mRNA increased in retina at the peak of 3 days after optic nerve crush. The VGF protein showed an increase after 7 days after optic nerve crush. Intravitreal administration of VGF peptide (AQEE 30) significantly suppressed retinal ganglion cell death after optic nerve crush. This finding suggests that VGF has a protective effect against retinal ganglion cell disorder.
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| Free Research Field |
神経化学
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