Role of omega-3 fatty acids in intestinal immunomodulating

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462704
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Tohoku University
• Principal Investigator: Wada Motoshi 東北大学, 医学系研究科, 准教授 (80372291)
• Co-Investigator(Kenkyū-buntansha): 工藤 博典 東北大学, 大学病院, 助教 (00723032) ; 仁尾 正記 東北大学, 医学系研究科, 教授 (70228138)
• Research Collaborator: Sakurai Tsuyoshi 東北大学, 医学系研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 腸管免疫 / マクロファージ / GPR120

Outline of Final Research Achievements

GPR120, which is one of G protein-coupled receptors, has many physiological functions through medium-chain or long-chain fatty acids like omega－3 fatty polyunsaturated acids as their ligands. We examined the pathological and functional distribution of GPR120 expression in mice gut tissue with immunofluorescent staining and found that GPR120 is especially highly expressed in distal small intestine and proximal colon tissue. We also found out that GPR120 and F4/80 positive cells co-localized. Thus, it is suggested that in distal intestine, especially ileocecal potion, GPR120 has some physiological functions and anti-inflammatory functions via gut macrophages.

Free Research Field

小児外科学