2017 Fiscal Year Final Research Report
Pathophysiology of gastroesophageal reflux in neurologically impaired children
| Project/Area Number |
26462706
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 胃食道逆流 / GER / 胃排出遅延 / 食道インピーダンスｐHモニタリング / 酸性GER / 非酸性GER |
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| Outline of Final Research Achievements |
Neurologically impaired(NI) patients showed a wide range of gastric emptying rates without any significant causal relationship between delayed gastric emptying and gastroesophageal reflux(GER). The results suggest that the proximal gastric accommodation, which is caused by adaptive gastric relaxation, is a more important factor for controlling GER than the acceleration of gastric emptying.
There was an increase in acid GER in NI pediatric patients with abnormal GER, whereas acid and nonacid GER were comparable in NI pediatric patients without abnormal GER. Although the underlying mechanism of our findings could not be fully explained, physiologically appropriate therapeutic approaches for GER disease in NI patents should include the reduction of acid GER to that of nonacid GER rather than the complete prevention of all GER.
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| Free Research Field |
小児外科
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