2016 Fiscal Year Final Research Report
Pathogenesis of cytokine storm in necrotizing enterocolitis develop a treatment strategy
| Project/Area Number |
26462711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Kubota Akio 和歌山県立医科大学, 医学部, 特命教授 (10161671)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 新生児壊死性腸炎 / サイトカインストーム |
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| Outline of Final Research Achievements |
Necrotizing enterocolitis(NEC) is a fetal inflammatory disease of premature infant.Although the pathogenesis is still unclear, we thought that the cytokine storm played an important role in etiology of NEC. We made a NEC model mice using Intrauterine growth restriction(IUGR) model mice with Intestinal loop causative test.We try to appear the role of inflammatory cytokines in NEC by measuring the blood cytokine levels in those mice. But It failed to reveal a significant elevation of inflammatory cytokines in NEC model mice.
We made a NEC model cell line as simple model.I thought that it could be useful for future research of NEC etiology and treatment
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| Free Research Field |
新生児外科学
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