Renegerate intestine using biotube which has ability of self-regenerate capacity

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462713
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Saitama Medical University
• Principal Investigator: Terawaki Kan 埼玉医科大学, 医学部, 講師 (00372384)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 再生医療 / 腸管不全

Outline of Final Research Achievements

The aim of this study was to regenerate intestine using collagenous connective tissue membranes (=named Biotube) which were prepared by embedding silicon tube as a mould in subcutaneous pouches in dorsal skin. The novelty of this study was not to use stem cells such as ES cells or iPS cells. It was quite difficult to keep the anastomosis lesion of the intestine in abacterial condition because the generation of intestinal endotherial cells was rather slow and the leakage of intestinal fluids stream colud not be stopped.
In order do this experiment successfully, we are planning to use esophagus alternatively and try to evaluate whether endotherial cells and muscles of eshohagus can regenerate or not.

Free Research Field

小児外科、再生医療