Elucidation of the pathology of lymphedema and search for effective lymphangiogenesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Hokkaido University
• Principal Investigator: Oyama Akihiko 北海道大学, 大学病院, 講師 (70374486)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: リンパ浮腫 / リンパ管新生因子 / 低酸素応答因子 / 炎症性細胞

Outline of Final Research Achievements

As a treatment for lymphedema, conservative treatment and surgical treatment including lymphaticovenous anastomosis are performed, but treatment is often difficult. Therefore, effective treatment for lymphedema including new lymphatic regeneration is desired. It has been reported that VEGF-C which is one of vascular endothelial cell growth factors induces lymphatic regeneration in lymphedema tissues by stimulating lymphatic endothelium and promoting migration of lymphatic endothelial cells . In this study, we aimed to develop efficient treatment of lymphedema, and aimed to analyze the role played by VEGF-C in lymphedema tissue and factors related to the regulation of expression of VEGF-C in edematous tissue. It was demonstrated that the expression of inflammatory cells such as macrophages and hypoxia response factors such as HIF-1 alpha were increased in the lymphedema.

Free Research Field

唇顎口蓋裂、リンパ浮腫