Elucidation of IL-17 function and production in the wound healing and the role in chronic wounds

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462723
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Tohoku University
• Principal Investigator: TAKEDA ATSUSHI 東北大学, 医学系研究科, 非常勤講師 (30333800)
• Research Collaborator: TAKAGI Naoyuki 東北大学, 医学系研究科, 助教 ; TANNO Hiromasa 東北大学, 医学系研究科, 助教
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 創傷治癒 / IL-17 / サイトカイン

Outline of Final Research Achievements

Interleukin-17 (IL-17) is a proinflammatory cytokine. The role of this cytokine in the wound healing process is not fully clarified. In this study, IL-17A knockout mice showed promoted wound healing and decreased neutrophil accumulation compared with wild-type mice, and the administration of recombinant IL-17A led to delayed wound closure, accelerated neutrophilic accumulation and improved wound repair with treatment of a neutrophil elastase inhibitor. Neutrophils, macrophages and gamma-delta T cels showed IL-17A expression after wounding in wild-type mice.
These results indicated that IL-17A hampared the wound healing process and neutrophilic inflammation caused by IL-17 led to impaired wound healing in skin.

Free Research Field

創傷治癒学