Mechanism of diabetic complications in the skin

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462730
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Okano Junko 滋賀医科大学, 医学部, 准教授 (50447968)
• Co-Investigator(Kenkyū-buntansha): 小島 秀人 滋賀医科大学, 医学部, 教授 (00225434) ; 森本 尚樹 関西医科大学, 医学部, 准教授 (40378641)
• Co-Investigator(Renkei-kenkyūsha): Morimoto Naoki 関西医科大学, 医学部, 准教授 (40378641)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 糖尿病性難治性潰瘍 / バリア機能 / ホメオスタシス / 糖尿病マウスモデル

Outline of Final Research Achievements

Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are required to prevent the development of sepsis. In the present study, we demonstrated that hyperglycemia induces skin barrier dysfunction with alterations of epidermal integrity, using non-wounded skin of type 1 diabetic mice. Disrupted homeostasis in the non-wounded skin could be the underlying mechanisms of non-healing diabetic skin complications.

Free Research Field

創傷治癒学