2016 Fiscal Year Final Research Report
The effect of stretch stimuli on human skin equivalents
| Project/Area Number |
26462732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Research Collaborator |
TAKAHASHI Ken 岡山大学, 医歯薬学総合研究科 システム生理学, 助教 (50432258)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メカノメディスン / human skin equivalent / 伸展培養 / 基底膜 |
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| Outline of Final Research Achievements |
In this study, we developed systems that enable application of stretch stimuli to HSEs during formation. Consequently, we found that in the ST group, the epidermal layer is thicker than NST group. Furthermore, synthesis of basement membrane proteins and deposition in the basal layer are increased; therefore, a more developed basement membrane is formed. Further research using this system may elucidate effects of stretching on skin properties and wound healing. In addition, application to an in vitro model of a hypertrophic scar is also expected.
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| Free Research Field |
形成外科学
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