Resolution of fused suture in craniosynostosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Teikyo University (2015-2016); Juntendo University (2014)
• Principal Investigator: Komuro Yuzo 帝京大学, 医学部, 教授 (90306928)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 頭蓋縫合早期癒合症 / 先天異常 / 骨延長術 / 頭蓋形成術

Outline of Final Research Achievements

This research was performed to elucidate cause of craniosynostosis which is a rare condition. We performed an operation in 8 patients of craniosynostosis and extracted a bone specimen from the fused suture.It was observed in X-ray radiography, three-dimensional CT and MRI whether intracranial pressure was reduced and the skull shape was improved by an operation. It was confirmed that these improvements are obtained by performing posterior calvarial vault distraction method which is an innovative surgical procedure we developed.
The osteoblasts in the patent and fused sutures were almost all positive for TGF-A1, -A2, and -A3. There was no distinct difference between activated osteoblasts and inactivated osteoblasts. The periosteum in patent and fused sutures tended to be positive for TGF-A2 and negative for TGF-A1 and -A3. Genetic expression of FGFR2 at the fused suture is being examined.

Free Research Field

形成外科学