A development of alveolar bone formation with platelet rich plasma/fibrin technique for cleft lip and palate

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462741
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Kanagawa Children's Medical Center (Clinical Research Institute)
• Principal Investigator: Shinji Kobayashi 地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 部長 (90464536)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口唇口蓋裂 / 骨移植 / 多血小板血漿

Outline of Final Research Achievements

Platelet rich plasma/fibrin(PRP/PRF) was grafted to accelerate bone formation in alveolus of cleft lip and palate patient under `the act on the safety of regenerative medicine` issued by the Ministry of Health, Labour and Welfare. As the result, there were no problems in all patients. The concentration of cytokine in PRP/PRF tended to be higher than in peripheral blood, though there were great differences between individuals. Meanwhile, in vitro, PRP/PRF did not facilitate the proliferation of human infant osteoblast cells, but histologically facilitated the bone differentiation.

Free Research Field

形成外科