Statins for post cardiac arrest syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462743
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: University of Tsukuba
• Principal Investigator: Nakayama Shin 筑波大学, 医学医療系, 講師 (60596443)
• Co-Investigator(Kenkyū-buntansha): 田口 典子 筑波大学, 医学医療系, 准教授 (90569774)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 心肺蘇生 / スタチン

Outline of Final Research Achievements

Statins (HMG-CoA reductase inhibitors) exert numerous pleiotropic effects and have been shown to attenuate ischemic injury in different rodent models of stroke. This study was conducted cardiac arrest and cardiopulmonary resuscitation (CA/CPR) in mice and tested the hypothesis that statins after CPR improves survival rate and neurological outcomes. Combined treatment with hydrophilic and lipophilic statins improved survival rate and neurobehavioral scores at 4 days after CPR. Statins also decreased inflammatory cytokines, upregulated Nitric Oxided Synthase, and attenuated brain edema and histological damages in the striatum and hippocampus. These data suggest that statins after CA/CPR would be beneficial in the post resuscitation phase via systemic pleiotropic effects including anti-inflammatory response and stabilize vascular reactivity.

Free Research Field

麻酔・蘇生学