2016 Fiscal Year Final Research Report
TEMPO-RNP is a new thrapeutic agent for acute septic models: the effect of anti-oxidants converted into the micelle
| Project/Area Number |
26462744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NGASAKI Yukio 筑波大学, 数理物質系, 教授 (90198309)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 敗血症 / 酸化ストレス |
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| Outline of Final Research Achievements |
We implied that landiolol ameliorated septic-induced cardiomyopathy and the survival rate in septic rats induced by lipopolysaccharide(LPS). We also reported the beneficial effects of landiolol for multiple organs in some papers and paid attention to oxidative stress in sepsis. We expected that TENPO-RNP have the therapeutic roll for sepsis, which is the agent micellized antioxidant and delivered to the focus in patients. But, we could not obtain the results and only showed its possibility.
In LPS-induced septic rats, d-ROM, the marker of oxidative stress in blood, increased compared to control rats. On the other hand, pNF-H, the marker of neural damage in blood, could elicit the mechanism and be presentative for sepsis-induced cognitive impairment.
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| Free Research Field |
集中治療医学 救急医学 循環器学
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