2017 Fiscal Year Final Research Report
Investigation of the role of bone marrow-derived cells in multiple organ dysfunction
| Project/Area Number |
26462752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤野 和典 滋賀医科大学, 医学部, 助教 (70402716)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 多臓器不全 / proinsulin陽性細胞 / 骨髄由来細胞 |
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| Outline of Final Research Achievements |
Multiple organ failure (MOF) is a refractory disease condition with high mortality rate, and its mechanism has not been elucidated yet. Based on the similarities between complications of MOF patients and diabetic complications, we considered that there is a common mechanism between them, and histological investigation and clinical studies were conducted for proinsulin positive cells reported to appear in diabetic mice. Histologically, proinsulin positive cells appeared not only in diabetic patients but also in patients with MOF. In clinical studies, the mortality rate was high in the group of patients with increased insulin mRNA expression in the peripheral white blood cells. The appearance of proinsulin positive cells may be involved in the mechanism of MOF.
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| Free Research Field |
多臓器不全
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