2016 Fiscal Year Final Research Report
Reoxygenation with 100% oxygen following hypoxia in mice causes apoptosis
| Project/Area Number |
26462754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 低酸素症 / 100％酸素蘇生 / 空気蘇生 |
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| Outline of Final Research Achievements |
The present study showed that reoxygenation with 100% oxygen after hypoxia increased inflammatory cytokines and caspase-3 mRNA expressions compared with 21% oxygen in adult mice. The present study provides some insight as to why 100% oxygen has harmful effects on adult brain after hypoxia as well as neonatal brain. In the clinical situation, the oxygen concentration after hypoxia might affect neurological outcomes in adult.
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| Free Research Field |
蘇生
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