Analysis of HIF-1 mediated energy metabolism during septic multiple organ dysfunction syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462759
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Yokohama City University
• Principal Investigator: YAMAGUCHI Osamu 横浜市立大学, 附属病院, 准教授 (20174609)
• Co-Investigator(Kenkyū-buntansha): 東條 健太郎 横浜市立大学, 医学部, 助教 (80737552) ; 柳 大介 横浜市立大学, 附属市民総合医療センター, 助教 (80638586) ; 倉橋 清泰 横浜市立大学, 附属市民総合医療センター, 准教授 (50234539)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 敗血症 / 臓器不全 / 低酸素誘導性因子

Outline of Final Research Achievements

We measured HIF-1α protein levels and ATP concentrations in the lung tissues from septic mice. At the early stage, HIF-1α protein and ATP levels were increased. On the other hand, HIF-1α protein levels returned to the control level and ATP concentrations were decreased in the lung tissues at the late stage.
These observations suggest that modulation of HIF-1 might have therapeitic effects against septic mulitiple organ dysfunction syndrome through the improvement of energy metabolism.

Free Research Field

集中治療医学