Amiodarone does not affect brain injury in a rat model of transient forebrain ischemia.

2018 Fiscal Year Final Research Report

• Project/Area Number: 26462763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nara Medical University
• Principal Investigator: Inoue Satoki 奈良県立医科大学, 医学部, 病院教授 (50295789)
• Co-Investigator(Kenkyū-buntansha): 川口 昌彦 奈良県立医科大学, 医学部, 教授 (60275328)
• Research Collaborator: Yamanaka Koutaro
• Project Period (FY): 2014-04-01 – 2019-03-31
• Keywords: 脳蘇生 / 脳虚血 / アミオダロン

Outline of Final Research Achievements

Amiodarone may have neurotoxicity that can affect patient outcomes when used during cardiopulmonary resuscitation (CPR) although this drug has been commonly prescribed to patients during CPR. This study investigated possible neuronal effects of amiodarone in a rat model of transient forebrain ischemia. Administration of amiodarone immediately after transient forebrain ischemia did not worsen spatial cognitive function or neuronal survival in the hippocampal CA1 region in rats. The current results must be applied with caution in humans. However, they indicate that the potential neurotoxicity induced by amiodarone during resuscitation after cardiac arrest may be neglectable.

Free Research Field

麻酔、集中治療

Academic Significance and Societal Importance of the Research Achievements

アミオダロンの脳への影響を見た研究は少なく、貴重な実験だったと思える。心肺蘇生時のアミオダロンの抗不整脈薬としての地位は広く認められており、このアミオダロンが心肺蘇生だけでなく脳蘇生にも効果があることが認められれば限定した使用でなく全例にその使用が推奨されるべきであると考えられたが、一方で脳毒性の問題もあった。今回の実験で現在の心停止後の蘇生に対するアミオダロンの使用に対する懸念も新たな期待もないことが示唆された。