2016 Fiscal Year Final Research Report
Approach to inflammatory lung diseases by improving paracellular enviroment
Project/Area Number |
26462767
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Emergency medicine
|
Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | 炎症性肺疾患 / ARDS / 高濃度酸素 |
Outline of Final Research Achievements |
1) We exposed human vascular endothelial cells to hyperoxia, and found the induction of interleukin-8 gene expression. This response was exacerbated under the co-incubation with tumor necrosis factor alpha or lipopolysaccharide, suggesting the exaggerated toxicity of hyperoxia in patients under critical condition. We further found the involvement of intracellular pattern-recognition receptors in this mechanism. 2) We found that differentiation of human embryonic stem cells into lung epithelial cells was facilitated by an air-liquid interface method. 3) We previously found the exaggerated bleomycin-induced acute lung injury in interleukin-17 deficient mice. By the current analysis, involvement of pathways not including dendritic cells or interleukin-12 were suggested. 4) We comprehensively analyzed lung cytokines in patients with acute respiratory distress syndrome, and found the involvement of interleukin-1beta, interferon-gamma, and interleukin-17.
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Free Research Field |
呼吸器集中治療
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