Evaluation of the mechanisms how beta blockade therapy for sepsis can protect sepsis-induced organ injuries

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Keio University
• Principal Investigator: Takeshi Suzuki 慶應義塾大学, 医学部(信濃町), 講師 (80327600)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 敗血症 / β遮断薬 / Tリンパ球 / アポトーシス / 免疫能

Outline of Final Research Achievements

In this study, I evaluated the effect of beta blockade therapy on spleen T-lymphocytes in sepsis. After confirmation that catecholamine stimulation induced spleen T-lymphocytes apoptosis in a dose dependant manner, I evaluated the effect of beta blockade therapy on normal spleen T-lymphocytes, which were reduced according to the severity of sepsis. I used a cecum ligation and puncture (CLP) model as a septic model, which was a golden standard model for sepsis. Beta blockade therapy maintained the number of normal spleen T-lymphocytes, which were reduced dramatically in septic model. This result suggests that the preservation of immune function through manintenance of T-lymphocytes may be one of beneficial effects of beta blockde therapy in sepsis.

Free Research Field

麻酔学、集中治療医学