2016 Fiscal Year Final Research Report
Molecular mechanism of selective autophagy against bacterial pathogens
| Project/Area Number |
26462776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | オートファジー / Rab GTPase |
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| Outline of Final Research Achievements |
We performed comprehensive analysis of Rab GTPase family proteins in autophagy against bacterial pathogens. We identified Rab35 as a novel autophagy regulator. Rab35 binds to NDP52 and regulates the recruitment of NDP52 to invading bacteria. We also found that NLRP4, intracellular pattern recognition receptor, is recruited to invaded bacteria and regulates Rho signaling via RhoGDI to promote the fusion between recycling endosomes and autophagosomes. The fusion step is required for the extension of autophagosome membranes and form complete autophagosomes. Taken together, we revealed how host cells recognize pathogens and induce selective autophagy.
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| Free Research Field |
細菌学
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