Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462783
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Okayama University
• Principal Investigator: Fujii Masae 岡山大学, 歯学部, 博士研究員 (30362685)
• Co-Investigator(Kenkyū-buntansha): 武部 祐一郎 岡山大学, 歯学部, 博士研究員 (00714677) ; 長塚 仁 岡山大学, 医歯薬学総合研究科, 教授 (70237535) ; 辻極 秀次 岡山理科大学, 理学部, 教授 (70335628)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 腫瘍微小環境 / 骨髄由来細胞 / 血球系細胞

Outline of Final Research Achievements

The activated tumor stroma participates tumor cell growth, invasion and metastasis has been the subject of recent studies. In the present study, bone marrow-derived cells in tumor stroma were traced using the GFP bone marrow transplantation model. The result revealed that a population of GFP positive cells showed peripheralis tumor par parenchyma more than tumor center. Cancer-associated fibroblasts (CAFs) represent the major cellular component of the stroma. Bone marrow-derived cells might differentiate into inflammatory cells (tumor associated macrophage(TAMs) and endothelial cells that suggested promote tumor invasion.

Free Research Field

口腔病理