2017 Fiscal Year Final Research Report
Elucidation of angio and lymphangiogenesis mechanism by novel oral cancer-related gene
| Project/Area Number |
26462790
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
國安 弘基 奈良県立医科大学, 医学部, 教授 (00253055)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KIRITA Tadaaki 奈良県立医科大学, 医学部, 教授 (70201465)
|
|---|
| Research Collaborator |
YAMAMOTO Kazuhiko
Bhawal Ujjal
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 口腔癌 / 新規マーカー / 浸潤・転移 |
|---|
| Outline of Final Research Achievements |
We found that N4BP2L1 and STOX2 are novel angiogenesis and lymmphangiogenesis d\factor in oral cancer. Expression of N4BP2L1 was regulated by the activation of miR-448. Overexpression of N4BP2L1 was significantly associated with nodal metastasis and poor prognosis in oral cancer specimens. We also revealed that MIA increased expression of STOX2 by paracrine manner in oral cancer cells. Furthermore, STOX2 expression was associated with acquisition of multidrug resistance and nodal metastasis in oral cancer. Our findings indicate that N4BP2L1 and STOX2 may be a useful diagnostic and therapeutic target in oral cancer.
|
| Free Research Field |
口腔病理学
|
