Investigation of the molecular basis of the inhibitory effect of novel NF-kB inhibitor on bone invasion by OSCC for clinical trial

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: Matsuo Kou 九州歯科大学, 歯学部, 教授 (70238971)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口腔扁平上皮癌 / NF-κB / IκBキナーゼβ / IMD-056

Outline of Final Research Achievements

Gingival oral squamous cell carcinoma (OSCC)frequently invade the maxilla or the mandibular bone and are associated with poor prognosis. Thus, we investigated whether the novel NFkB inhibitors suppress bone invasion by OSCC. NF-kB inhibitors suppress proliferation and stimulate apoptosis of OSCC cells in vitro and in vivo. NF-kB inhibitors also inhibit matrix metalloproteinase (MMPs) production in OSCC. Furthermore, NF-kB inhibitors have been shown to suppress osteoclastogenesis by reducing RANKL expression in animal models. Thus, inhibition of NF-kB activity may constitute a promising therapeutic approach to treat bone-invasive OSCC

Free Research Field

口腔病理学