Resolution of Oral Biofilme Formation at Early Stage

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462793
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: NAKAZAWA Futoshi 北海道医療大学, 歯学部, 教授 (60115053)
• Co-Investigator(Renkei-kenkyūsha): MASHIMA Izumi 日本学術振興会, 特別研究員 (60770782)
• Research Collaborator: CITRA F. Theodorea 北海道医療大学, 大学院歯学研究科, 大学院生 ; THAWEBOON Boonyanit Mahidol University, Department of Oral Microbiology, Faculty of Dentistry, 講師 ; THAWEBOON Sroisiri Mahidol University, Department of Oral Microbiology, Faculty of Dentistry, 教授
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口腔バイオフィルム / Veillonella / Streptococcus / メタゲノム解析 / 口腔清掃

Outline of Final Research Achievements

Ora biofilm cause dental caries and periodotal disease. Streptcoccus and Veillonella are known to have important roles in the biofilm formation at aerly stage.This study demonstrated the following results. 1. Auto inducer from V. tobetsuensis inhibited biofilm formation of S. gordonii. 2. Draft genome of V. tobetsuensis was revealed. 3. New method for identification of all veillonella species was established. 4. Based on metagenome analysis of saliva, it was demonstrated that Streptococcus species incresed in good oral hygiene, but Veillonella species incresde in poor ora hygiene. 5. Many unknown Veillonella species inhabited in oral cavities with poor oral hygiene.

Free Research Field

口腔細菌学