Elucidation and control of effect of short chain fatty acids on periodontopathogens

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462804
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: Yoshida Yasuo 愛知学院大学, 歯学部, 准教授 (10315096)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 短鎖脂肪酸 / 歯周病 / Porphyromonas gingivalis / 酪酸

Outline of Final Research Achievements

The concentration of short chain fatty acids (butyrate et al.), which is produced in the periodontal pockets, are approximately ten times more than that in the healthy pockets. In addition, butyrate induces apoptosis in human cells, including gingival fibroblasts and in T and B cells, and the molecule activates virus infected in human. In this study, to develop the medications that are inhibitors for enzymes associated with butyrate production, molecular basis on production of butyrate and propionate were elucidated by clarifying the properties of the purified enzymes.

Free Research Field

歯学