2016 Fiscal Year Final Research Report
Modulation of swallowing reflex by an endocannabinoid-degrading enzyme inhibitor (JZL184).
| Project/Area Number |
26462808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University (2015-2016)
Niigata University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 嚥下 / 嚥下障害 / 内因性カンナビノイド / 2-AG / 内因性カンナビノイド分解酵素阻害剤 / JZL184 / 上喉頭神経 |
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| Outline of Final Research Achievements |
The present study was designed to investigate whether swallowing reflex in rat is modulated by JZL184, an inhibitor of the main degradation enzyme of a major endocannabinoid named 2-arachydonoylglycerol (2-AG). Intrathecal (IT) application of JZL184 reduced the latency of onset of swallowing reflex evoked by electrical stimulation of the superior laryngeal nerve (SLN). Findings of immunohistochemical study indicated that JZL184 application (IT) reduced production of the degradation enzyme monoacylglycerol lipase (MAGL), thereby increased the accumulation of 2-AG in the swallowing center of the nucleus tractus solitaries. These findings suggest that increase accumulation of endocannabinoid by preventing its degradation in the swallowing center can facilitate the triggering of swallowing reflex.
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| Free Research Field |
口腔生理学
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