2016 Fiscal Year Final Research Report
Investigation of sensory integration in the insular cortex -multiple in vivo patch clamp analysis-
| Project/Area Number |
26462824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Research Collaborator |
AOKI Ryuhei
NAGAO Takahide
ODAI Reina
SAITO Yoshihiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 島皮質 / 侵害受容 / 錐体細胞 / patch clamp / ラット |
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| Outline of Final Research Achievements |
The spontaneous membrane potential oscillation of cortical pyramidal neuron is characterized by up state, a short depolarization period, and down state that included following after hyperpolarization (AHP) and resting membrane potential. Up state of agranular insular (AI) cortical pyramidal neurons was less exhibited compared with those of somatosensory cortical neurons. GABAA agonist increased and prolonged AHP. Electrical tongue stimulation induced EPSPs in AI neurons located 1 mm rostral from middle central artery with high incidence. In more rostral region, same stimulation induced IPSPs with low incidence.
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| Free Research Field |
歯科薬理学
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