2016 Fiscal Year Final Research Report
Roles of interleukin-33 in gingival Inflammation
Project/Area Number |
26462834
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Ohno Tatsukuni 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (80435635)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | IL-33 / 歯周炎 / マウスモデル |
Outline of Final Research Achievements |
Interleukin-33 (IL-33), which is a new member of the IL-1 family of cytokines, has been involved in Th2-mediated immune responses including host defense against nematode and allergic diseases. Unlike regular cytokines, IL-33 is released from necrotic damaged cells during tissue injury and acts as an alarmin. Thus, IL-33 may contribute to chronic inflammatory tissue diseases. In this study, we investigate the roles of IL-33 in the gingival inflammation. Wild-type and IL-33 knockout (KO) mice received Porphyromonas gingivalis (P.g)-injection into the molar gingiva and gingival inflammatory responses were evaluated. LPS-injection into gingiva enhanced IL-1b, TNF-a, and IL-33 mRNA expression in wild type mice, but not in IL-33 KO mice. Our results suggest dual roles of IL-33; protective role in early gingival inflammatory responses.
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Free Research Field |
免疫学
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