2016 Fiscal Year Final Research Report
A study on mechanism of bisphosphonate-related infection of the jaw .
| Project/Area Number |
26462837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tottori University |
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Principal Investigator |
RYOKE KAZUO 鳥取大学, 医学部, 特任教授 (20093635)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | HSC：ヒト間葉系幹細胞 / ＢＲＯＮＪ：ビスフォスフォネート関連顎骨壊死 / ヒト皮膚線維芽細胞 / 歯周靱帯線維芽細胞 / 細胞増殖能 / ＢＰ：ビスフォスフォネート / 骨芽細胞 / 骨免疫 |
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| Outline of Final Research Achievements |
1.We established HSC(Human Mesenchymal Stem Cell) enabling to monitor of bone differentiation.As for the remedy against BRONJ, the medication of PTH was examined using this HSC derived from the human bone marrow.The optimum administration of PTH was a dosage of 100ng/ml with 4-day intervals.An addition of BP to HSC demonstrated no any bone formation,which implied that BP could supress the osteoblastic formation. 2.BP inhibited both NHDF and HPdLF proliferation in dose dependency,especially the tendency was remarkable in the latter.Inhibiting of cell migration was marked in HPdLF.An expression of bFGF was detected in both HPdLF and NHDF groups after BP processing,but there was no signiticant difference between them.
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| Free Research Field |
医歯薬学
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