Involvement of NLRP3 inflammasome in oral lichen planus

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462842
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kochi University
• Principal Investigator: KITAMURA Naoya 高知大学, 教育研究部医療学系臨床医学部門, 講師 (70351921)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: インフラマソーム / 口腔扁平苔癬

Outline of Final Research Achievements

Although the pathogenesis of oral lichen planus (OLP) has not been elucidated, the possibility of an immune response based on localized excessive cytokine toward mucosal epithelial cells has been suggested. In this study, we investigated whether the activation of NLRP3 inflammasome is involved in the pathogenesis of OLP. As a result, it was revealed that the activation of NLRP3 inflammasome by metal nanoparticles in the oral mucosal epithelial cells and macrophages was involved with the pathogenesis of OLP.

Free Research Field

口腔外科