Drafting of a revised ACR criteria for Sjogren's syndrome.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Nagasaki University
• Principal Investigator: TAKAGI Yukinori 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30295084)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: シェーグレン症候群 / 超音波 / 診断基準

Outline of Final Research Achievements

Incorporating the US criteria as an alternative to one of the three ACR classification items achieved 89-91% sensitivity, 87-96% specificity and 89% or 92% accuracy, which was comparable to that of the original ACR classification. Furthermore, kappa analysis indicated that the results of the original ACR and US-replaced ACR classifications matched completely (κ = 0.960-0.974).Therefore,US can be used as an alternative to any of the three ACR classification items.
Also.multiple regression analysis indicated that the baseline US score before treatment was the most important factor [standardized regression coefficient (β) = -0.523, t-statistic (t) = -7.967, P < 0.001] in predicting negative outcomes in SS patients. Salivary gland US grading may help to predict outcomes of treatment for impaired salivary function in patients with SS.
These results suggest that US is a promising technique,which can be used as a practical item in the classification criteria of SS.

Free Research Field

歯科放射線学