Establishment of anti-invasion/metastasis therapy targeting integrin-related molecules in oral squamous cell carcinomas

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Oita University
• Principal Investigator: kawano Kenji 大分大学, 医学部, 教授 (50214664)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口腔扁平上皮癌 / 浸潤・転移抑制療法 / integrin / ILK / laminin 5 / HIF 1α / Her3/ErbB3

Outline of Final Research Achievements

This research project aims at the establishment of anti-invasion/metastasis therapy against oral squamous cell carcinomas (OSCC). OSCC of the tongue and oral floor were examined for expression of integrin-linked kainase (ILK), laminin 5, hypoxia-induced factor 1α (HIF 1α) and Her3/ErbB3. ILK was overexpressed in 67% of OSCC, and it was localized on cell membrane or in cytoplasm of cancer cells. Since ILK did not co-localized with laminin 5 in most of tumors, it was likely that ILK did not mediate the out-in signal via α3β1 integrin. When ILK overexression was compared with T classification, invasion pattern of cancer cells and treatment outcome, no clear correlations were observed between ILK and all of these factors. In conclusion, no molecular basis of the possibility of a novel molecular therapy targeting ILK has not been obtained yet.

Free Research Field

口腔外科学