2016 Fiscal Year Final Research Report
Influence of periodontal disease-causing bacteria infection on peritoneal dialysis
| Project/Area Number |
26462849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagoya City University |
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Principal Investigator |
IMAI Masaki 名古屋市立大学, 大学院医学研究科, 講師 (30440936)
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| Research Collaborator |
MIZUNO Masashi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 腹膜透析 / 歯周病 |
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| Outline of Final Research Achievements |
To assess influence of periodontal disease-causing bacteria infection on peritoneal dialysis (PD), we investigated the relationship between periodontal pathogenic bacterial infection an the tissue damage associated with PD were examined. We tried to detect periodontitis causative bacteria in peritoneal dialysis from patients. However, P. gingivalis which is a periodontitis causing bacterium could not be detected.
Next, rat C5a and C5adesArg were prepared in order to clarify in the model animals that bacterial infection and elevation of the concentration of anaphylatoxin directly exacerbate the inflammatory response. When C5a and C5adesArg were administered to rats, a marked inflammatory response was not detected with anaphylatoxin alone. As contrast, C5a administration with low concentration of LPS induced a strong inflammatory response. Interestingly, C5adesArg, that is inactivated C5a also enhanced inflammatory response when pre-administration of low concentration LPS.
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| Free Research Field |
免疫学
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