2016 Fiscal Year Final Research Report
Genome-wide analysis of epigenetics in the sialadenitis from Sjogren's syndrome
| Project/Area Number |
26462852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | シェーグレン症候群 / エピジェネティクス / DNAメチル化 |
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| Outline of Final Research Achievements |
We performed Genome-wide analysis of epigenetics in the sialadenitis from Sjogren's syndrome. The hypermethylations of E-cadherin and β-catenin; epithelium adhesion connection genes and MGMT; DNA repair enzyme gene were analyzed. The hypermethylation of E-cadherin, β-catenin and MGMT may be involved in the pathogenesis of Sjogren's syndrome. The hypermethylations of these genes may be therapeutic target for Sjogren's syndrome.
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| Free Research Field |
口腔病理学
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