2017 Fiscal Year Final Research Report
Search for salivary metabolome markers for cancer prediction and prognosis detection
| Project/Area Number |
26462860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
二藤 彰 鶴見大学, 歯学部, 教授 (00240747)
島田 明美 鶴見大学, 歯学部, 講師 (00339813)
杉本 昌弘 東京医科大学, 医学部, 教授 (30458963)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | メタボローム / 唾液 / 腫瘍 |
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| Outline of Final Research Achievements |
In this study, we performed salivary metabolome analysis to search for breast cancer specific and highly reliable biomarker. We investigate differential metabolites between breast cancer bearing mice and control mice, and found several candidate markers. In addition, we performed tracer experiments with 13C-glucose, and detected marker candidates highly reproducibly in tissues such as mammary glands, salivary glands, and blood. These results suggested that salivary metabolome analysis may be useful to detect cancer-specific metabolites.
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| Free Research Field |
医歯薬学
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