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2017 Fiscal Year Final Research Report

Search for salivary metabolome markers for cancer prediction and prognosis detection

Research Project

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Project/Area Number 26462860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTsurumi University

Principal Investigator

Shibata Tatsuya  鶴見大学, 歯学部, 講師 (90323708)

Co-Investigator(Kenkyū-buntansha) 二藤 彰  鶴見大学, 歯学部, 教授 (00240747)
島田 明美  鶴見大学, 歯学部, 講師 (00339813)
杉本 昌弘  東京医科大学, 医学部, 教授 (30458963)
Project Period (FY) 2014-04-01 – 2018-03-31
Keywordsメタボローム / 唾液 / 腫瘍
Outline of Final Research Achievements

In this study, we performed salivary metabolome analysis to search for breast cancer specific and highly reliable biomarker. We investigate differential metabolites between breast cancer bearing mice and control mice, and found several candidate markers. In addition, we performed tracer experiments with 13C-glucose, and detected marker candidates highly reproducibly in tissues such as mammary glands, salivary glands, and blood. These results suggested that salivary metabolome analysis may be useful to detect cancer-specific metabolites.

Free Research Field

医歯薬学

URL: 

Published: 2019-03-29  

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