2016 Fiscal Year Final Research Report
Elucidation of inhibitory mechanisms by salivary histatin in influenza viral infection and its induced inflammation
| Project/Area Number |
26462861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
WANG Pao-Li 大阪歯科大学, 歯学部, 教授 (20213613)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 唾液蛋白質 / ヒスタチン |
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| Outline of Final Research Achievements |
Salivary protein histatins have antimicrobial properties and protect living organism from pathogens. Although there are antiviral actions in saliva, the detailed salivary components are not clarified. Because histatins are innate immune-related factors involved in biophylaxis, histatins are likely to have anti-influenza viral actions. In this study, histatin has turned out to be a salivary protein that inhibits the influenza viral constituent. It has also become apparent that histatin associates with another influenza viral constituent and a gram-positive bacterial one and inhibits them. These are the results of finding the new physiological function of salivary protein. These results are also connected with the future development of antiviral and anti-inflammatory agents.
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| Free Research Field |
分子生物学・生化学・免疫学
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