Development of a plan of the new C5a receptor antagonist

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462863
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Hyogo Medical University
• Principal Investigator: Nishiura Hiroshi 兵庫医科大学, 医学部, 助教 (90284760)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: RP S19 / C5a受容体 / アポトーシス / マクロファージ / 貪食処理 / 急性炎症

Outline of Final Research Achievements

All apoptotic cells express C5a receptor or produce and release its antagonist/agonist ligand ribosomal protein S19 (RP S19) polymer. When one of binding motives of RP S19 polymer binds to the C5a receptor on apoptotic cells in an autocrine manner, a lifespan of apoptotic cells is shorten through an activation of an apoptosis-inducing transcription factor delta-type lactoferrin. Next, another binding motives of RP S19 polymer bind to the C5a receptor on macrophages in an paracrine manner, a phagocytic time of apoptotic cells is shorten through an activation of a calcium channel-opening factor wild-type annexin A3.

Free Research Field

実験病理学